Not quite - the layout of even the most reform will have the ark containing the Torah facing towards Jerusalem. The congregational seating can be arranged any which way but it is invariably focused towards the ark. In any event many prayers are performed standing and the devout will turn to face the ark at such times regardless of which way their chair may be positioned.
This response does not however disregard the possibility that there are devout Jews who may turn towards Jerusalem at those particular moments when it is most appropriate to do so (call to worship, etc), it's just that many early REFORM temples did not consider Jerusalem, the Holy Temple, or zionism as an important part of the Reform movement, and therefore did not build the structure with any significance to the congrgation facing east.