They were usually at war with their neighbors, a fact usually glossed over by present-day romantic views of Native American life. In a sense, this constant warfare helped keep Indian populations in check, so you could say that the Indian's primary natural enemy was himself.
That they remained too few in number to reduce the continent to a waste-land before English settlers got here should not be confused with a modern sensibility regarding the "sanctity of the earth."
So, basically, they were the neolithic equivalent to the aliens in the movie Independence Day.