Well, in fact, yes. The Bible indicates that we, as Christians, won't know the hour or day of the Lord's coming. However, if we were "in" the Tribulation (i.e., were still here) we would definitely know that time of the Lord's coming.
The events inside the Tribulation time are marked out (1,260 days and 1,260 days or 42 months and 42 months, with the abomination of desolation that Jesus Christ talked about, from Daniel, at that midpoint, being the Antichrist, standing in the then-existing Temple in Jerusalem, proclaiming himself to be God). When we see that -- then there is no question as to the exact day of the return of the Lord. It's 1,260 days later -- exactly.
And Paul told us not to be fooled into believing that the Day of the Lord had come. And he said to comfort one another, in the knowledge of the coming of the Lord, to take us in a twinkling of an eye.
While those who remain may live through the wrath of God, those who are "righteous in the blood of Christ" (by their faith in the promise of Christ for the forgiveness of sin and their resurrection for all who believe on Him) will not be living through it.
Ah yes, but when is the "wrath of God" poured out? Not at the beginning of the Tribulation, but toward the end, in the bowl judgements. Read "The Pre-Wrath Rapture of the Church" by Marvin Rosenthal :)