Twice a non-Democrat has run with a disgruntled Democrat as his running mate and it didn't work out well either time--William Henry Harrison with John Tyler in 1840, Abraham Lincoln with Andrew Johnson in 1864. So Tulsi and Manchin should be ruled out...and they would not help the ticket anyway.
That was a good ticket because they represented youth and optimism.
Bush 41 was seen as out of touch after his "read my lips, no new taxes" remark.