NO.
Words mean things, and people look like idiots when they misuse words as above.
Pore over == to examine carefully
Toe the line == to follow the rules exactly
Lose == to experience any of several forms of failure
Loose == to release
As a notoriously bad speller who, at least in his defense, is trying to improve, I feel obliged to point out that the example referenced was a spelling error, and not one of misuse, as the two words in question “pour” and “poor” are homophones and sound identical in spoken language.