I recall reading a “Field and Stream” article, probably in the early 60s, where a grizzly attacked some guy. He emptied his 45 point blank into the bear, and it still managed to tear him up. I guess it all comes down to shot placement.
I would like to find that article, to add to the database.
I and colleagues have been searching with a fair amount of diligence.
If you find it, please let me know.