Impeachment is a political act. Weigh the consequences in doing so. It’s very unlikely Biden will be removed from office by the Senate. Since impeachment is political, you can make the same points by impeaching cabinet members. More than likely, cabinet members will resign before there is a vote. If Republicans control the Senate, then they can control who replaces the retiring cabinet member. Well, maybe. Not if McConnell has any say about it.
I’d start by going after Biden’s cabinet secretaries. Mayorkas and Garland first. Followed by Granholm. Biden gets no replacements. Just whittle his government down to “acting” this or that.