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Tiny discovery in Chinese lab could be a big deal in stopping Covid-19
AsiaOne ^ | SEPTEMBER 02, 2022 | Zhang Tong

Posted on 09/03/2022 1:41:30 PM PDT by nickcarraway

click here to read article


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1 posted on 09/03/2022 1:41:30 PM PDT by nickcarraway
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To: nickcarraway

2 posted on 09/03/2022 1:41:47 PM PDT by nickcarraway
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To: nickcarraway

Too late, the pandemic is over.


3 posted on 09/03/2022 1:51:38 PM PDT by packagingguy
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To: nickcarraway

Tiny discovery. Did Xi pull down his pants at the lab?


4 posted on 09/03/2022 1:56:15 PM PDT by Right Brother
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To: nickcarraway

LOL, and the side effects?
Fool me once shame on you fool me twice Darwin award.


5 posted on 09/03/2022 2:01:31 PM PDT by JayGalt (For evil men to accomplish their purpose it is only necessary that good men should do nothing.”)
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To: JayGalt

The deep state does not want a cure. Crickets. Nothing will happen.


6 posted on 09/03/2022 2:04:47 PM PDT by Trumpet 1 (US Constitution is my guide.)
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To: nickcarraway
Anything that comes out of China is a scam.
7 posted on 09/03/2022 2:04:49 PM PDT by Harmless Teddy Bear (The nation of france was named after a hedgehog... The hedgehog's name was Kevin... Don't ask)
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To: Harmless Teddy Bear

Anything that comes out of China is a scam.

***********

Well they seem to be scamming the USA and the rest of the
world without much effort. They got something going for them


8 posted on 09/03/2022 2:08:14 PM PDT by deport
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To: nickcarraway

That’s the answer! Give me a good big dose of the Chinese nanoparticles!


9 posted on 09/03/2022 2:09:28 PM PDT by 9YearLurker
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To: nickcarraway

It’s a trap.


10 posted on 09/03/2022 2:12:00 PM PDT by Lazamataz (The firearms I own today, are the firearms I will die with. How I die will be up to them.)
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To: nickcarraway

A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination

https://www.nature.com/articles/s41565-022-01177-2


11 posted on 09/03/2022 2:12:28 PM PDT by FarCenter
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To: packagingguy

*


12 posted on 09/03/2022 2:13:12 PM PDT by unread ("It's not enough that we do our best; sometimes we have to do what's required." W. Churchill.)
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To: deport
Go buy everything the Chi-Coms say if you like.

Watch out for the poisoned fake toothpaste.

13 posted on 09/03/2022 2:15:54 PM PDT by Harmless Teddy Bear (The nation of france was named after a hedgehog... The hedgehog's name was Kevin... Don't ask)
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To: FarCenter

Conclusions
Here we have described the 2D CIPS NS as an effective nano-glue capable of selectively capturing the SARS-CoV-2 virus by binding its S protein, thereby inhibiting infection of host cells. The binding affinity of CIPS to the S-protein RBD is <1 pM, suggesting the formation of very stable complexes. The effective binding of CIPS to eight of the eleven ACE2-binding amino acid residues of the SARS-CoV-2 RBD accounts for the efficient inhibition of viral infectivity. The RBD mutations displayed by SARS-CoV-2 VOCs do not affect their binding to CIPS, and indeed CIPS proved broadly effective in inhibiting all the viral VOCs, with efficacy evident in both preventive treatment and therapeutic strategies in vitro and in vivo. In addition, the similarity of the RBD of SARS-CoV-2 to the RBDs of other coronaviruses (for example, SARS) suggests that CIPS is also potentially useful in broadly inhibiting coronavirus infectivity (Supplementary Fig. 18).

Notably, the affinity of CIPS for SARS-CoV-2 RBDs (KD < 1 pM) is substantially higher than that of therapeutic mAbs, which have an affinity in the range from 23 pM to 100 nM25,28,42, similar to the binding affinity between the RBD and ACE2 (11–17.4 nM in our hands, 14.7 nM reported for S-protein binding to ACE236). This suggests that only a few of the currently available mAbs may have sufficient affinity for the RBD to efficiently compete with its binding to ACE2, and that their efficacy against different VOCs varies greatly, with a substantial loss of efficacy for the Omicron VOC, which displays 15 mutations in the RBD15. Thus, compared with mAbs, CIPS displays a higher affinity for RBD and a broader specificity, which enable it to bind and neutralize all SARS-CoV-2 VOCs.

CIPS has been found safe and biocompatible both in vitro (Supplementary Fig. 4) and in vivo (Extended Data Fig. 7, Supplementary Figs. 19 and 20, and Supplementary Tables 8 and 9), being quickly removed from the lung, most probably degraded by macrophages, and eliminated through urine (Extended Data Fig. 7d). After intranasal administration, CIPS does not enter the blood stream (Extended Data Fig. 7), is unable to cause haemolysis, does not induce inflammatory activation of macrophages and is unable to bind IgG (Supplementary Fig. 21). The SARS-CoV-2 adsorbed on CIPS can be efficiently phagocytosed by macrophages, shuttled to phagolysosomes and completely degraded together with its carrier. Another important consequence of the CIPS-dependent virus uptake by macrophages and its intracellular degradation is the expected generation of viral peptides and their presentation in the context of MHC II molecules, that is, the pathway of antigen presentation that induces a strong antibody response. Thus, the capacity of CIPS to direct the virus to macrophages has the double advantage of promoting viral destruction and triggering antiviral adaptive immunity.

Thus, CIPS is a safe, biocompatible and biodegradable 2D NM capable of inhibiting infection and promoting the elimination of SARS-CoV-2 (Fig. 6). The binding between CIPS and the SARS-CoV-2 S-protein RBD is ~10,000-fold stronger than the affinity of the virus for ACE2, suggesting that the CIPS-captured virus will not be released and will not infect cells. Notably, CIPS binding is 23- to 100-fold stronger than that of the best mAbs, and its broad capacity for RBD binding makes it equally effective against all the tested VOCs, as well as for other coronaviruses. Its broad-spectrum efficacy, storage stability and good biocompatibility make CIPS a promising anti-SARS-CoV-2 drug candidate. The viscous flypaper-like and selective binding capacity of CIPS for the SARS-CoV-2 S protein also makes it particularly promising as a surface-coating material and decontamination agent, to contain viral spread and increase safety during handling in laboratory and clinical settings.


14 posted on 09/03/2022 2:15:58 PM PDT by FarCenter
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To: nickcarraway

No thanks.


15 posted on 09/03/2022 2:16:40 PM PDT by Salamander (Please visit my profile page help save my beloved dog's life. https://www.givesendgo.com/G2FUF)
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To: Harmless Teddy Bear
"Nano, nano!"


16 posted on 09/03/2022 2:17:56 PM PDT by Salamander (Please visit my profile page help save my beloved dog's life. https://www.givesendgo.com/G2FUF)
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To: Trumpet 1

The deep states cure is the next bio attack.


17 posted on 09/03/2022 2:20:58 PM PDT by JayGalt (For evil men to accomplish their purpose it is only necessary that good men should do nothing.”)
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To: nickcarraway

Hard pass.


18 posted on 09/03/2022 2:22:22 PM PDT by Herodes
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To: nickcarraway

This is fantastic news. Cudos should go to the person who discovered it!


19 posted on 09/03/2022 2:28:31 PM PDT by maxwellsmart_agent (AL)
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To: nickcarraway
The cure will be sold by Ama Chinazon with deliveries to your door the next day. Tracking chip contained within is not optional.
20 posted on 09/03/2022 2:29:03 PM PDT by Da Coyote
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