I’m generally in favor of separatist movements, such as Lega Nord in Italy and the Quebec Separatists.
I would prefer that the US split up, not remain under a false unity that gives us political outcomes that combine the worst features of progressivism and laissez-faire capitalism.
I’d support separatists who have actually done it, such as Taiwan and Ukraine, or Pakistan for that matter, and allow them to keep and defend their hard-won separation, because they earned it. But it’s not Plan A. America is infected with some real stupid ideas right now, but once upon a time it was infected with Puritanism, No-nothing-ism, Barn-burner abolitionists, Nativism, genocidal hatred of Indians, Jim Crow, etc. The country, unified, has overcome all that and more, because “e pluribus unum” is not just a phrase on a dollar bill.