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Two Common Over-the-Counter Compounds Reduce COVID-19 Virus Replication by 99% in Early Testing
Science Tech Daily ^ | December 12, 2021 | University of Florida Health

Posted on 12/14/2021 4:57:01 AM PST by null and void

A pair of over-the-counter compounds has been found in preliminary tests to inhibit the virus that causes COVID-19, University of Florida Health researchers have found.

The combination includes diphenhydramine, an antihistamine used for allergy symptoms. When paired with lactoferrin, a protein found in cow and human milk, the compounds were found to hinder the SARS-CoV-2 virus during tests in monkey cells and human lung cells.

The findings by David A. Ostrov, Ph.D., an immunologist and associate professor in the UF College of Medicine’s department of pathology, immunology and laboratory medicine and his colleagues, are published in the journal Pathogens.

“We found out why certain drugs are active against the virus that causes COVID-19. Then, we found an antiviral combination that can be effective, economical, and has a long history of safety,” Ostrov said. Sigma Receptors

Molecular docking of sigma-2 receptor ligands that exhibit antiviral activity against SARS-CoV-2. Credit: University of Florida

Due to his earlier research with colleagues at UF, Ostrov already knew diphenhydramine was potentially effective against the SARS-CoV-2 virus. The latest discovery has its roots in a routine meeting of scientists with the Global Virus Network’s COVID-19 task force. One researcher presented unpublished data on federally approved compounds that inhibit SARS-CoV-2 activity, including lactoferrin.

Like diphenhydramine, lactoferrin is available without a prescription. Ostrov thought about pairing it with diphenhydramine and ran with the idea. In lab tests on human and monkey cells, the combination was particularly potent: Individually, the two compounds each inhibited SARS-CoV-2 virus replication by about 30%. Together, they reduced virus replication by 99%.

The findings, Ostrov said, are a first step in developing a formulation that could be used to accelerate COVID-19 recovery. It also raises the prospect of further study through an academic-corporate partnership for human clinical trials focused on COVID-19 prevention. Additional research into the compounds’ effectiveness for COVID-19 prevention is already underway in mouse models.

To establish their findings, the research team focused on proteins expressed in human cells known as sigma receptors. In COVID-19 cases, the virus “hijacks” stress-response machinery, including sigma receptors, in order to replicate in the body. Interfering with that signaling appears to be the key to inhibiting the virus’s potency. “We now know the detailed mechanism of how certain drugs inhibit SARS-CoV-2 infection,” Ostrov said.

Data from the experiments show that a highly specific sigma receptor binding drug candidate (with pain relieving properties), and formulated combinations of over-the-counter products (such as diphenhydramine and lactoferrin) have the potential to inhibit virus infection and decrease recovery time from COVID-19, the researchers concluded.

While the findings are encouraging, Ostrov cautions against self-medicating with either diphenhydramine or lactoferrin as a COVID-19 prevention or treatment. The type of lactoferrin used in the research differs slightly from the type that is commonly available to consumers, he noted. Lactoferrin is commonly used as a supplement to treat stomach and intestinal ulcers, among other uses.

Reference: “Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells” by David A. Ostrov, Andrew P. Bluhm, Danmeng Li, Juveriya Qamar Khan, Megha Rohamare, Karthic Rajamanickam, Kalpana K. Bhanumathy, Jocelyne Lew, Darryl Falzarano, Franco J. Vizeacoumar, Joyce A. Wilson, Marco Mottinelli, Siva Rama Raju Kanumuri, Abhisheak Sharma, Christopher R. McCurdy and Michael H. Norris, 20 November 2021, Pathogens. DOI: 10.3390/pathogens10111514

Scientists from UF’s Emerging Pathogens Institute, College of Pharmacy and Clinical and Translational Science Institute, the University of Saskatchewan and the Saskatchewan Cancer Agency collaborated on the research.


TOPICS: Culture/Society
KEYWORDS: 666; covid; otc; va666ine; vaxholes; vaxzis
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To: Ellendra

Thank you for the info.


61 posted on 12/14/2021 10:22:37 AM PST by MayflowerMadam (When government fears the people, there is liberty.)
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To: steve86

“You should stop. First generation antihistamine use is strongly correlated with development of dementia later on.”

What does “later on” mean? I’m already 80 yrs old.


62 posted on 12/14/2021 10:31:50 AM PST by billyboy15
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To: steve86
You may be interested in this.

CLINICAL MISINFORMATION: THE CASE OF BENADRYL CAUSING DEMENTIA

May 22, 2013

In July 2010, Campbell, Boustani and colleagues published the results of a 6-year longitudinal observational study on the cognitive function of 1,600 African Americans over the age of 70 and the association with medications with anticholinergic side effects.[2] The study enrolled individuals who were cognitively normal at baseline. The participants were then reevaluated at least once for cognitive decline at 3 and 6 years of follow-up. Data on patient’s medications with anticholinergic side effects were based on participants reported medication use as well as over-the-counter and prescription bottles belonging to the patients.[3]

The results of the Campbell study are as follows: of the study participants, 179 of 1,652 (11%) were deemed to be exposed to “definite” anticholinergic medications. In that group, the odds ratio for “cognitive impairment” was 1.43, which was not statistically significant to a p-value of 0.05. When corrected based on the number of drugs with anticholinergic effects an individual was taking, the odds ratio for cognitive impairment was 1.46 with a p value of .0181. However, overall the authors conclude that their data did not support the hypothesis that the use of anticholinergic medications increased the risk of alzheimer’s dementia and that the results simply “suggested” a link between this class of medications and “mild cognitive impairment”.[2]

After forty-five minutes of researching and using information databases that are only accessible to me via my medical school library, I had found that the information my friend’s original fear was based on was at best inconclusive. A study with internal validity only to African-Americans over the age of 70 which “suggested” that anticholinergic use may be linked to mild cognitive impairment had, through the evolution of information, been applied to the general population and concluded that medications like Benadryl caused memory loss.

https://www.clinicalcorrelations.org/2013/05/22/clinical-misinformation-the-case-of-benadryl-causing-dementia/

63 posted on 12/14/2021 10:44:06 AM PST by billyboy15
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To: billyboy15

It is generally accepted in in medicine that anticholinergic use does result in later symptomology (causal). I used to keep a list of references in my bookmarks but would have to re-search those now. There were multiple studies, not RCTs, of course, but convincing longitudinal studies. I myself was taken off an Rx drug for this reason.

Believe what you want.


64 posted on 12/14/2021 10:57:58 AM PST by steve86 (Prophecies of Maelmhaedhoc O'Morgair (Latin form: Malachy))
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To: null and void; faucetman; metmom; 2ndreconmarine; Fitzcarraldo; Covenantor; Mother Abigail; EBH; ...
(Title):"Two Common Over-the-Counter Compounds Reduce COVID-19 Virus Replication by 99% in Early Testing "

null and void :" Tomorrow's headline: "Lactoferrin Banned By Fauci"
"Hope I'm wrong..."

“Like diphenhydramine, lactoferrin is available without a prescription. Ostrov thought about pairing it with diphenhydramine and ran with the idea.
In lab tests on human and monkey cells, the combination was particularly potent:
Individually, the two compounds each inhibited SARS-CoV-2 virus replication by about 30%.
Together, they reduced virus replication by 99%. “ (Emphasis mine)

What are the two compounds which reduced viral replication :
diphenhydramine = benedryl (sold as sleep aid, allergy medication)
lactoferrin = milk (bovine and/or human)… which probably explains why children may be less affected

65 posted on 12/14/2021 11:02:30 AM PST by Tilted Irish Kilt
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To: Tilted Irish Kilt

Next week a drug company will apply for a patent on a drug that combines the two.🙄


66 posted on 12/14/2021 11:29:38 AM PST by BiteYourSelf ( Earth first we'll strip mine the other planets later.)
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To: null and void

In vitro. Where is the study?


67 posted on 12/14/2021 11:43:15 AM PST by MarMema
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To: billyboy15

Prozac does, and in vivo.


68 posted on 12/14/2021 11:44:20 AM PST by MarMema
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To: solachristo

This was done in petri dishes.


69 posted on 12/14/2021 11:45:28 AM PST by MarMema
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To: null and void

When my brother and sister in-law were sick, I was exposed to Delta. I was taking Benadryl and making myself a Mocha latte daily for breakfast and lunch. I was also taking the daily C, Zine, B, and D.

I got mild symptoms but never got real sick. They might be on to something here.


70 posted on 12/14/2021 11:56:58 AM PST by DEPcom (Make the enemy live up to its own book of rules)
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To: Tilted Irish Kilt
Something to keep an eye on for confirmation, thanks for posting.

See tagline.

71 posted on 12/14/2021 11:59:08 AM PST by OKSooner (All thinking people should read "The Real Anthony Fauci" by RFK Jr.)
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To: steve86

“Believe what you want.”

I will believe what makes sense after research on the subject.

Send me some info if you have it.


72 posted on 12/14/2021 12:01:12 PM PST by billyboy15
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To: null and void

3 antihistamines are being looked at because they are also ace2 inhibitors

https://m.ufhealth.org/news/2020/existing-antihistamine-drugs-show-effectiveness-against-covid-19-virus-cell-testing

https://sbgg.org.br/wp-content/uploads/2021/01/6-ANTI-HISTAMIN.pdf

azelastine
Diphenhydramine
Hydroxyzine


73 posted on 12/14/2021 1:35:37 PM PST by HollyB
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To: null and void

Someone upstairs is really looking out for me.

In January 2020 while in Thailand and got Covid real bad, I took lots of Benadryl and Hydroxychloroquine... This was prior to anyone knowing what worked.

I always take Benadryl when I get a chest cough to stop the sinus drain and the Hydroxychloroquine was a prophylactic for malaria as I spent a week traveling by boat on the Mekong River.


74 posted on 12/14/2021 2:28:47 PM PST by tired&retired (Blessings )
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To: MarMema

The vax didn’t get as far as petri dishes before being forced on the public.


75 posted on 12/14/2021 4:16:45 PM PST by bgill (Which came first, the vax or the virus?)
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To: EBH; ThunderSleeps; null and void; SeekAndFind; Wonder Warthog; rktman; saintgermaine; All

I had found a detailed Chinese study on lactoferrin in various stages of maternal lactation in various ethnicities and assorted regions. Then my Chromebook erased all my tabs and that page, and I only found this aummary.
https://pubmed.ncbi.nlm.nih.gov/30189612/
https://www.researchgate.net/publication/326341264_Lactoferrin_level_in_breast_milk_a_study_of_248_samples_from_eight_regions_in_China

It seems the earliest milk has the highest lactoferrin content and it lowers over time and stabilizes after the third month from birth. Now I will find some data on animal milk which is far lower in lactoferritin than human milk. I wonder if any studies have been done on the degree of illness in breast fed babies versus cows milk or factory formulas

https://viva.org.uk/health/a-comparison-between-human-milk-and-cows-milk/ While this study does not refer specifically to ferritin, there are some interesting comments under IRON. The chart comparing vitamin and mineral content of cow and human milk is also of interest.

Human milk is rich in lactoferrin, with a concentration around 1–2 mg/mL [7–9], whereas lactoferrin concentration in ruminant milk is 10–100 times lower than in human milk (in the range of 0.02–0.2 mg/mL) [10, 11].Mar 19, 2014
This was the best (only?) article I found comparing lactoferrin in humans, goats, and cows.
https://www.researchgate.net/publication/260149810_Characterization_of_goat_milk_lactoferrin_N-glycans_and_comparison_with_the_N-glycomes_of_human_and_bovine_milk


76 posted on 12/14/2021 8:08:07 PM PST by gleeaikin (Question authority!)
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To: Sacajaweau; null and void; SeekAndFind; All

Annual vaccines, the money machine for big pharma. I wonder if failure to find vaccine for AIDS was becaue it would have been a multi-year vaccine like mumps, tetanus, etc., rather than annual. Current AIDS treatment is multiple drugs given daily for life. Why would big pharma ever want an AIDS vaccine?
Is that why Fauci failed to promote one.


77 posted on 12/14/2021 8:13:06 PM PST by gleeaikin (Question authority!)
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To: gleeaikin

Plenty of lactoferrin supplements on Amazon. Already got plenty Benadryl.


78 posted on 12/15/2021 7:33:41 AM PST by Wonder Warthog (Not Responding to Seagull Snark)
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bkmk


79 posted on 12/15/2021 7:36:52 AM PST by mad_as_he$$ (This will be a hot extract.)
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To: gleeaikin

I had read hay fed cows have more lactoferrin in the milk than grass fed cows. Don’t ask me why. I try and drink organic grass fed cow milk. Same idea as with eggs, etc. I need to find a local farm for eggs.


80 posted on 12/15/2021 10:47:55 AM PST by HollyB
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