Ego, ambition, and turmoil: Inside one of biotech’s most secretive startups [2016 re mRNA vaccines]

Stat ^ | 2016 Sept 13 | Damian Garde

[Meet the New Boss]

CAMBRIDGE, Mass. — At first glance, Moderna Therapeutics looks like the most enviable biotech startup in the world. It has smashed fundraising records and teamed up with pharmaceutical giants as it pursues a radical plan to revolutionize medicine by transforming human cells into drug factories.

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Moderna’s technology promised to subvert the whole field, creating therapeutic proteins inside the body instead of in manufacturing plants. The key: harnessing messenger RNA, or mRNA.

In nature, mRNA molecules function like recipe books, directing cellular machinery to make specific proteins. Moderna believes it can play that system to its advantage by using synthetic mRNA to compel cells to produce whichever proteins it chooses. In effect, the mRNA would turn cells into tiny drug factories.

It’s highly risky. Big pharma companies had tried similar work and abandoned it because it’s exceedingly hard to get RNA into cells without triggering nasty side effects.

snip

Delivery — actually getting RNA into cells — has long bedeviled the whole field. On their own, RNA molecules have a hard time reaching their targets. They work better if they’re wrapped up in a delivery mechanism, such as nanoparticles made of lipids. But those nanoparticles can lead to dangerous side effects, especially if a patient has to take repeated doses over months or years.

Novartis abandoned the related realm of RNA interference over concerns about toxicity, as did Merck and Roche.

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“I would say that mRNA is better suited for diseases where treatment for short duration is sufficiently curative, so the toxicities caused by delivery materials are less likely to occur,” said Katalin Karikó, a pioneer in the field who serves as a vice president at BioNTech.

[Meet the New Boss]

Interesting article about mRNA vaccine development from 2016, before the current politicization and authoritarianism enveloped the topic.

Note the text from the article: "those nanoparticles can lead to dangerous side effects, especially if a patient has to take repeated doses over months or years"

Numerous doctors have pointed out concerns over the toxicity of the spike protein generated by the mRNA vaccines, but as we see from this article the scientists creating the vaccines were worried about adverse effects from the lipid nanoparticles.

Now that the vaccines have failed to meet expectations and demonstrate waning effectiveness over just a few months, the Biden regime and the corporate media oligopoly are calling for the general public to take booster injections of these lipid nanoparticles every several months ad infinitum into the future, or until a more profitable patented drug from Big Pharma is hailed as a replacement.

[Diogenesis]

it was never tested, because the animals died.
so it was used for PEOPLE, for all people,
for children, for infants, for the nursing,
for the pregnant, for those with neoplasms hidden,
for those infirmed, for all ... untested.

untested. the companies CEOs and families did not take it.

they said, they did not want to “cut in line”.

they demanded IMMUNITY. for them.

[M_Continuum]

My belief is that will be novavax. Here’s an article from Nature on the history of the mRNA vaccine. Moderna had to have bioNtech, that’s who had it first. https://www.nature.com/articles/d41586-021-02483-w

[Jaded]

mark