The urgent need for metallo-β-lactamase inhibitors: an unattended global threat0(covid causing antibacterial resistance )

https://pubmed.ncbi.nlm.nih.go ^ | 2021 Jul 8 | Maria F Mojica 1, Maria-Agustina Rossi 2, Alejandro J Vila 3, Robert A Bonomo 4

[RomanSoldier19]

Due to their superior tolerability and efficacy, β-lactams are the most potent and prescribed class of antibiotics in the clinic. The emergence of resistance to those antibiotics, mainly due to the production of bacterial enzymes called β-lactamases, has been partially solved by the introduction of β-lactamase inhibitors, which restore the activity of otherwise obsolete molecules. This solution is limited because currently available β-lactamase inhibitors only work against serine β-lactamases, whereas metallo-β-lactamases continue to spread, evolve, and confer resistance to all β-lactams, including carbapenems. Furthermore, the increased use of antibiotics to treat secondary bacterial pneumonia in severely sick patients with COVID-19 might exacerbate the problem of antimicrobial resistance. In this Personal View, we summarise the main advances accomplished in this area of research, emphasise the main challenges that need to be solved, and the importance of research on inhibitors for metallo-B-lactamases amidst the current pandemic.

[RomanSoldier19]

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[blueplum]

resistance to... antibiotics, mainly due to the production of bacterial enzymes called β-lactamases...

currently available β-lactamase inhibitors only work against serine β-lactamases, whereas metallo-β-lactamases continue to spread, evolve, and confer resistance to all β-lactams, including carbapenems. research on inhibitors for metallo-B-lactamases [is needed]

So what are carabaspenems?
last line of defense antibacterials:

Carbapenems are a class of beta-lactam antibiotic that are active against many aerobic and anaerobic gram-positive and gram-negative organisms. ...Of all the beta-lactam antibiotics, carbapenems possess the broadest spectrum of activity and the greatest potency against bacteria. Because of this, they are often reserved for more severe infections or used as “last-line” agents.

https://www.drugs.com/drug-class/carbapenems.html

[RomanSoldier19]

[WWG1WWA]

“Science” right out of the Eugenicist playbook of Soros, Gates and Faux’s Trilogy. Masks are causing bacterial pneumonia.

[RideForever]

We had this problem before CoVID. It was amped up by NIH and CDC with recommendation of use of ‘hand sanitizer’ for a virus unaffected by it. So we have been dumping waste antibacterials into the environment, and super bugs have emerged over the past decade.

[RomanSoldier19]

https://www.usgs.gov/special-topic/water-science-school/science/pharmaceuticals-water?qt-science_center_objects=0#qt-science_center_objects