Whenever a law prevents free access or the use of a product for individual use, that law risks infringing on costitutional rights that as you have noted often go far beyond the original intent. However you ought to note that “legalization” and “normalization” of drug use has resulted and will continue to result in the destruction of many individuals and families which are the foundation of any vibrant culture. The press at one time reported on individual overdose deaths. They rarely report on such deaths or other drug related deaths such as accidents, shootings , domestic violence and murders under the influence. Nor do they report on the devastating effects on familiies when a loved one dies of an overdose or drug related death. Nor do they report on the agony of trying to live with a habitual “recreational” drug user. Constitutional rights seem very secondary to those who have suffered the real ramifications of habitual drug use be it legal or illgal.
You forgot to include in the list alcohol, which does far more damage to society and individuals than all illegal drugs combined.
It’s logically sound to make the argument that should be the first substance banned extra-constitutionally.