Question from the peanut gallery. How did they make the leap from killing 100% of animals during developmental testing to producing vaccines that are (generally considered) safe? There must have been some change or innovation in the mRNA technology that made this possible. That is, the developers must have solved some key problem that had been stymying them. Do you happen to know what that problem was and how they solved it?
I've heard this myth so many times, but every time I ask for a link to the study where an mRNA vaccine killed all the animals in animal trials, I get crickets for a response. So I'll ask again: do you have a link to a study where an mRNA vaccine was being tested and all the animals died?
The Pfizer and Moderna vaccines were successfully tested with mice and rhesus macaques. All the animals lived. All of them showed the anticipated immune response. All of them survived the challenge trials. There was no problem that needed to be solved relating to animals dying. The only problems with mRNA vaccines were that they A) were too expensive and complex to make at scale until the technology matured and B) how to deliver the mRNA to cellular cytoplasm before the nonspecific immune system destroyed the mRNA itself. Both of those challenges were solved.