Replies

(This is the first statement from the abstract)

"Respiratory syncytial virus (RSV) is the single most important cause of serious lower respiratory tract disease in infants and young children worldwide and a high priority for vaccine development. Despite over 50 years of research, however, no vaccine is yet available. One block to vaccine development is an incomplete understanding of the aberrant memory response to the formalin-inactivated RSV vaccine (FI-RSV) given to children in the 1960s. This vaccine caused enhanced respiratory disease (ERD) with later natural RSV infection. Concern that any non-live virus vaccine may also cause ERD has blocked development of subunit vaccines for young children. A number of animal FI-RSV studies suggest various immune mechanisms behind ERD. However, other than limited data from the original FI-RSV trial, there is no information on the human ERD-associated responses.",

(This is the last satement from the summary discussion)

"In summary, our in vitro model of human immune responses to RSV is consistent with animal model data that show the ERD-risk of FI-RSV through priming innate responses to direct T cells towards type-2. A combination of biomarkers in dendritic cells such as increased OX40L/Jagged-1 expression and decreased IL-12/IFN-α production and naïve T cells pulsed with stimulated dendritic cells such elevated Gata3 and ROR-γt expression provide robust measures of immune responses likely associated with ERD risk. This in vitro human model presents a tool to evaluate a vaccine’s risk of predisposing to ERD that should help move the field closer to developing a subunit, non-live virus vaccine for young children."

My non-medical interpretation

This article confirms the risk of ERD, and provides a tool to measure and evaluate the ERD risk.

My personal experience

My sister lives in a senior assisted living facility. She received both the first and second Covid-19 MRNA "vaccinations". One week after the second shot she was sent to the emergency room with severe breathing problems, and diagnosed with pneumonia (a quite severe ERD). She spent more than a month in the hospital and a rehab center, fortunately nearly recovered as of now, but with lingering breathing problems.

Any connection to the Covid-19 "vaccine"? Who knows???