In critical care, we see free radical injury and fibrosis of the Lunds with Inspired fraction greater than 60%. It is pretty rapid so we do everything we can to keep inspired fractions at or below 60%. Sometimes it is damn near impossible.
It is a head scratcher when I read the reactions of those here who buy into every new high protein diet, high dosage vitamin or cannabis derived supplement as the answer to all of their medical and age related problems. While the same group seems to disregard the benefits of the old adage about staying active and eating a balanced diet.
I was glad to see a healthy amount of skepticism in this thread.