Posted on 06/03/2020 3:42:37 PM PDT by absalom01
We conducted a randomized, double-blind, placebo-controlled trial across the United States and parts of Canada testing hydroxychloroquine as postexposure prophylaxis. We enrolled adults who had household or occupational exposure to someone with confirmed Covid-19 at a distance of less than 6 ft for more than 10 minutes while wearing neither a face mask nor an eye shield (high-risk exposure) or while wearing a face mask but no eye shield (moderate-risk exposure). Within 4 days after exposure, we randomly assigned participants to receive either placebo or hydroxychloroquine (800 mg once, followed by 600 mg in 6 to 8 hours, then 600 mg daily for 4 additional days). The primary outcome was the incidence of either laboratory-confirmed Covid-19 or illness compatible with Covid-19 within 14 days.
RESULTS We enrolled 821 asymptomatic participants. Overall, 87.6% of the participants (719 of 821) reported a high-risk exposure to a confirmed Covid-19 contact. The incidence of new illness compatible with Covid-19 did not differ significantly between participants receiving hydroxychloroquine (49 of 414 [11.8%]) and those receiving placebo (58 of 407 [14.3%]); the absolute difference was −2.4 percentage points (95% confidence interval, −7.0 to 2.2; P=0.35). Side effects were more common with hydroxychloroquine than with placebo (40.1% vs. 16.8%), but no serious adverse reactions were reported.
CONCLUSIONS After high-risk or moderate-risk exposure to Covid-19, hydroxychloroquine did not prevent illness compatible with Covid-19 or confirmed infection when used as postexposure prophylaxis within 4 days after exposure. (Funded by David Baszucki and Jan Ellison Baszucki and others; ClinicalTrials.gov number, NCT04308668. opens in new tab.)
(Excerpt) Read more at nejm.org ...
Bottom line: when used in this study, didn't help, but didn't hurt.
No zinc, yet another fake study and a waste of time.
Prophylaxis is not to treat the disease, it’s to prevent it. I would say this is the first actual strike against using it as a prophylaxis. But I’m no medical professional.
The little known secret of this test, something that most people in the know understand.....
It is like Kit without the Kat..
It is like...well you get it..
NO ZINC supplement.
Who do they think they are fooling?
Don’t answer i already know..
...as Postexposure Prophylaxis for Covid-19
—
How about taking it *preexposure”?
“No zinc, yet another fake study and a waste of time.”
Link does not work for me. Did they state no Zinc? What about AZ?
These biased studies just refuse to use the French Study, Dr Zek and other Drs. protocols of the three chemical cocktail. Someone needs to call them out high and hard. Can we just call them Mengeles studies screwing with patients outcomes at this point.
India has that in trial. If you click through to the site, the authors specifically note that they didn’t study pre-exposure use, since the Indian health system was doing a giant trial already.
I’m waiting for Dr. Zelenko’s to be published. He’s stated, though, that it’s a retrospective analysis and not a double-blind, so it will be criticized.
This isn’t the end of the NEJM trial, if I read the report correctly. They’re basically saying that HCQ alone had a small positive effect, though no serious complications.
I’m hoping that if Dr. Zelenko is able to report a strong positive result for his full regimen.
OF COURSE they ‘found’ no prophylaxis effect when they were intentionally looking for there to be none by intentionally excluding the +zinc regimen.
Yes I am saying that the NEJM and Lancet ARE dishonest.
I read that fewer (11.8%) developed symptomatic illness when treated with hydroxychloroquine than the placebo (14.3%), but that it did not reach statistical significance.
Also, there were no cardiac arrhythmias. And nobody died.
This looks like a well run study as far as it goes. Sure it would have been better to have enough participants so that additional groups could be given zinc with AZT, zinc without AZT, and AZT without zinc. However that might have been beyond the resources of the study.
I think the major problem with the study is that they are giving the zinc shortly after exposure and then testing for illness. I’d hypothesize that the major benefit of receiving HCQ days after exposure would be a reduction in the severity of the illness instead of avoiding the contraction of the illness.
Hopefully this study is continuing and will report on illness severity later and is just reporting their first available results now.
As medical studies go, 800+ people is not a large study. The results on that size study couldn’t be considered definitive, surely. Also, if I read the excerpt right, the participants were not all actually tested for COVID later; some of them had symptoms that might have been COVID (but also might not have been).
“Prophylaxis is not to treat the disease, it’s to prevent it.”
EXACTLY!!
AZT and Zinc is for treatment.
I’ve read a few articles where several hospitals are using it as prophylaxis in high risk employees.
Well, the NEJM has a long history of suffering under political influence.
I’m old enough to remember the apalling Arthur Kellerman “study” they published in 1993 that pretended to show that gun ownership itself posed an enhanced risk of homicide in people’s homes.
So, yeah, they’re political, with a history of liberal bias.
“Yes I am saying that the NEJM and Lancet ARE dishonest.”
There was a letter sent to Lancet signed by 120 doctors and scientists pointing out the NUMEROUS flaws in their data.
They should test Vitamin D levels vs getting disease. Since it varies widely by person, can be retrospective.
“Did not include AZT or Zinc, and has not reported final outcomes for all cases.”
Exactly.
Hydroxychloroquine + either AZT or Doxycycline AND Zinc within 5 days of positive symptoms/nasal test has, I believe, over a 90% success rate.
Worked for me.
This study, as it were, showed that using HCQ in a circumstance nobody said would help, for a thing nobody said it would do, didn’t really help much.
And it did so in a pretty bizarre way.
I think they were trying to address the claim that, if you take HCQ, you might have less chance of getting the virus.
But that isn’t what they tested. First, they administered 4 days after exposure. By that time, some people are already infected; at least, by that time the virus has made it into the body. Nobody has said HCQ can seek out and stop the virus.
THe CLAIM was that if you take HCQ with zinc, it will allow cells to be saturated with zinc, and then the cells won’t take up the virus. Obviously, that won’t work if you wait until after you HAVE the virus, and don’t take zinc.
But not for preventing an infection, that claim is that it reduces the severity of the infection. This wasn’t testing that at all, it was seeing if taking HCQ by itself 4 days after exposure could stop the disease.
I would note that, if you get exposed to the Flu, and get vaccinated 4 days after exposure, you are highly likely to get the flu.
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