I reviewed the scientific literature on hydroxychloroquine (HCQ), azithromycin (AZ), and their use for COVID-19. My conclusions:
- HCQ-based treatments are effective in treating COVID-19, unless started too late.
- Studies, cited in opposition, have been misinterpreted, invalid, or worse.
- HCQ and AZ are some of the most tested and safest prescription drugs.
- Severe COVID-19 frequently causes cardiac effects, including heart arrhythmia. QTc prolonging drugs might amplify this tendency. Millions of people regularly take drugs having strong QTc prolongation effect, and neither FDA nor CDC bother to warn them. HCQ+AZ combination, probably has a mild QTc prolongation effect. Concerns over its negative effects, however minor, can be addressed by respecting contra-indications.
- Effectiveness of HCQ-based treatment for COVID-19 is hampered by conditions that are presented as precautions, delaying the onset of treatment. For examples, some states require that COVID-19 patients be treated with HCQ exclusively in hospital settings.
- The COVID-19 Treatment Panel of NIH evaded disclosure of the massive financial links of its members to Gilead Sciences, the manufacturer of a competing drug remdesivir. Among those who failed to disclose such links are 2 out of 3 of its co-chairs.
- Despite all the attempts by certain authorities to prevent COVID-19 treatment with HCQ and HCQ+AZ, both components are approved by FDA, and doctors can prescribe them for COVID-19.
By the time the National Institutes of Health issued its non-recommendation of HCQ, questions were being raised as to whether this was really about just hating Trump. I wrote about that here.
Because along with the NIH's non-recommendation for HCQ (which wasn't as bad as the press touted, but enough for a round of negative media stories), there also was an enthusiastic NIH recommendation in late April for Gilead's Remdesivir, same company the NIH directors had a lot of conflicts of interest in.
Take that, Trump! Except that Trump issued high praise for that drug too, and that didn't set off a barrage of negative press stories the way HCQ did.
I’ve read China may own the patent to Remdesivir.
MEANWHILE, WE HAVE SOMETHING INTERESTING GOING ON IN THE BACKGROUND -— LOBBYING !!
See here from NPR:
TITLE: Gilead Lobbying Rose As Interest In COVID-19 Treatment Climbed
(EXCERPT)
Gilead Sciences, the drugmaker behind the experimental COVID-19 treatment remdesivir, spent more on lobbying Congress and the administration in the first quarter of 2020 than it ever has before, according to federal filings.
The pharmaceutical company spent $2.45 million on lobbying in the first three months of the year, a 32% increase over the $1.86 million it spent in the first quarter of 2019.