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To: yoe
"...what could be more controlled than a prison...?"

In case you are not being facetious, I will explain some of the difficulty with this issue.

First, the word "control" in the context of a scientific experiment refers to the effort to eliminate as much as possible the effects on the outcome of anything other than the difference between one treatment or another.

This is typically accomplished by selecting two groups randomly from one population.

Some have suggested that there is an ethical problem with denying HCQ (hydroxychloroquine) to people ill with COVID-19. This presupposes that the result of the experiment would support the hypothesis that the HCQ treatment is superior to the alternative. There have been medical experiments that have had such marvelously positive results that the experiment has been halted prematurely. The criteria for halting the experiment should be spelled out before the experiment begins.

If an experimenter has such a bias in favor of one outcome over another, such that an ethical question might arise, then the ethical thing to do is to let someone else without that bias conduct the experiment. The first French study saw the doctor remove from his negative outcomes six patients.

The second point I would make has to do with the original hypothesis that the experiment is meant to test. I think the numbers commonly seen indicate that about 98% of patients recover without any novel treatment. That means that any experiment with only 50 or even 100 patients is unlikely to result in a definitive statement about the efficacy of a particular alternative treatment.

Badly done science doesn't become well done science simply by getting the right conclusion.

35 posted on 04/08/2020 1:11:53 PM PDT by William Tell
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To: William Tell

>>The first French study saw the doctor remove from his negative outcomes six patients.<<

I appreciate your perspective on the evidence thus far. That decision of the French doctor bothered me, although I did assume that he had a valid reason to do so and that he was attempting an honest assessment of the efficacy of HCQ.

People also keep claiming that long-term lupus patient on HCQ are not getting Covid-19, but if that were definitively true, I would think there would already be a write up to that effect, but I haven’t seen one. And you would think it would be a relatively easy check to make too, especially with all the specialization in medicine today. How hard would it be for a major hospital system to collate all of its patients on long-term HCQ for lupus or arthritis and then survey them for Covid-19? The list itself should be trivial to acquire. A major pharmacy business could also be a source, for that matter.

There is definitely a bandwagon effect underway for HCQ. Personally, I suspect it’s well justified, but there’s still that nagging doubt about it in my mind. That said, I would ask for it if I come down with Covid-19, and quickly (and zinc and zithro too.)


37 posted on 04/08/2020 2:21:35 PM PDT by Norseman (Defund the Left....completely!)
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To: William Tell
Badly done science doesn't become well done science simply by getting the right conclusion.

Do you think dead people really care about the science? Yeah me neither.

41 posted on 04/08/2020 3:17:36 PM PDT by itsahoot (Welcome to the New USA where Islam is a religion of peace and Christianity is a mental disorder.)
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