Results from a Controlled Trial of Hydroxychloroquine for COVID-19

ContagionLive ^ | April 4, 2020 | KENNETH BENDER, PHARMD, MA

[Lazamataz]

The initial results from a placebo-controlled trial of hydroxychloroquine for COVID-19 indicate that patients hospitalized with mild illness recovered more quickly with addition of the drug than with placebo at the start of a standard treatment. The results also suggest that hydroxychloroquine might convey some protection against the illness worsening.

Zhan Zhang, MD, of Renmin Hospital of Wuhan University, Wuhan, China, and colleagues reported results from 62 patients randomized to receive either placebo or hydroxychloroquine 200mg twice daily for 5 days on admission in addition to standard treatment consisting of oxygen therapy, and unspecified regimens that could include antiviral and antibacterial agents, and immunoglobulin with or without corticosteroids.

"The data in this study revealed that after 5 days of hydroxychloroquine treatment, the symptoms of patients with COVID-19 were significantly relieved, manifesting as shorten(ing) in the recovery time for cough and fever," Zhang and colleagues reported.

"At the same time, a larger proportion of patients with pulmonary inflammat(ion) has been partially absorbed in the hydroxychloroquine treatment group, indicating the immune modulation and anti-inflammatory properties of hydroxychloroquine in non-malarial diseases," the researchers indicated.

The measure of time to clinical recovery was defined as return of normal body temperature and cough relief, maintained for 72 hours. A chest CT, obtained before starting the experimental regimen and 1 day after, on day 6 of hospitalization, was characterized as either exacerbated, unchanged, or improved—with 50% or more reduction in opacification classified as significantly improved.

In comparison to the 31 patients on placebo, the 31 receiving the hydroxychloroquine adjunct to standard treatment were reported to have significantly shorter average time to recover normal body temperature . ...

"Despite our small number of cases, the potential of hydroxychloroquine in the treatment of COVID-19 has been partially confirmed," Zhang and colleagues concluded.

[Lazamataz]

The following people can kindly STFU:

Ohio state Rep. Tavia Galonski (D)

CNN

Associated Press in general, and HOPE YEN, CALVIN WOODWARD and ERIC TUCKER in particular.

NBC

CBS, MSNBC, and Joe Scarborough

[Meatspace]

“Zhan Zhang, MD, of Renmin Hospital of Wuhan University, Wuhan, China...”

Doctors and scientists in Wuhan have the most experience with COVID-19 and by their own reported facts, the disease has been eliminated in Wuhan.

[SeekAndFind]

RE: Zhan Zhang, MD, of Renmin Hospital of Wuhan University, Wuhan, China, and colleagues

This was already reported over a week ago.

The bottom line is Hydroxychloroquine works better than the control group in this small study.

[Black Agnes]

The terms ‘China’ and ‘reported facts’ are often at variance.

Buyer beware.

[null and void]

Trump was right? NONSENSE!!!

*gnashing of teeth* *wailing* *lamentations of their women*

Bring Out Your Dead

Post to me or FReep mail to be on/off the Bring Out Your Dead ping list.

The purpose of the “Bring Out Your Dead” ping list (formerly the “Ebola” ping list) is very early warning of emerging pandemics, as such it has a high false positive rate.

The false positive rate was 100%.

At some point we may well have a high mortality pandemic, and likely as not the “Bring Out Your Dead” threads will miss the beginning entirely.

*sigh* Such is life, and death...

If a quarantine saves just one child's or one old fart’s life, it's worth it.

[crz]

It is China, so no comment.

Follow the examples from the French instead.

[markman46]

A very good treatment to releave symptoms, remember this does not remove the virus, need to find out how people do after they stop taking the meds 5 days 10days after.

[reasonisfaith]

As long as you don’t join the initiative to talk down hydroxychloroquine.

This has been an anti-Trump deep state scheme.

Working for the deep state is a clear sign of following a low IQ idea.

[Jane Long]

Do you have a link to ‘this does not the remove the virus’?

I could swear I read a report, recently, that said the patient showed NO signs of virus, after receiving and recovering from, this HCQ protocol treatment.

I will look for the link that I saw.

Thanks.

[SeekAndFind]

RE: need to find out how people do after they stop taking the meds 5 days 10days after.

We have several doctors here in the USA who can answer that question. I think they all RECOVERED.

So, what I’ve see so far are:

1) An Infectious disease specialist from France, Dr. Didier Raoult successfully using it on over a 100 patients and PUBLISHING the results in two separate papers.

2) A Jewish Doctor, Dr.Vladimir Zelenko taking it prophylactically for himself and successfully treating over 800 patients with it in upstate New York with outstanding results.

3) A New Jersey Doctor Stephen Smith using it successfully on his many patients in his clinic saying: ‘I think this is the beginning of the end of the pandemic’

SEE HERE: https://www.foxnews.com/media/dr-stephen-smith-on-effectiveness-of-hydroxychloroquine-with-coronavirus-symptoms-beginning-of-the-end-of-the-pandemic

4) A Long Island Doctor, Dr. Mohammud Alam, an infectious disease specialist affiliated with Plainview Hospital, who said 81 percent of infected Covid patients he treated at three Long Island nursing homes recovered from the contagion.

See here:

https://nypost.com/2020/04/04/long-island-doctor-tries-new-hydroxychloroquine-for-covid-19-patients/

NOTE: THESE ARE ELDERLY PATIENTS, the ones who have the worst mortality rates.

And now

5) A Los Angeles Doctor who swears by it after seeing excellent results ( this article : http://freerepublic.com/focus/f-news/3832233/posts )

[Regulator]

The action of Zinc was not used in this study.

It’s far more effective when it’s part of it. That’s what attacks the transcription and replication mechanism in the viral shell.

Nice information, but incomplete.

[Fido969]

For God’s sake, please stop posting this study. Post some new studies, please.

[Dan in Wichita]

If I was sick with the China virus and was given a placebo for this study, I’d be really upset (if I survived)

[MrEdd]

If started before encountering the virus, then it prevents the virus from even getting an initial hold.

We have known that since February.

Which is why there have been people demanding that healthcare workers be given a maintenance dose until this is under control.

[ProtectOurFreedom]

Yep...this AP headline and article yesterday in the Coeur d'Alene Press (very lib paper) REALLY pisses me off. It's by two of the three "journalists" you listed...

"AP FACT CHECK: Trump pitches drug unapproved for coronavirus," by Calvin Woodward & Eric Tucker, April 5, 2020.

WASHINGTON (AP) — President Donald Trump is pitching a medicine for COVID-19 sufferers that science has not concluded is effective or safe for their use. “Take it,” he said of the drug. For people sick with the coronavirus, he said Sunday, “It can help them but it’s not going to hurt them.” In fact, it may or may not help some people, and it may or may not hurt them.

His straight-ahead advocacy of hydroxychloroquine, a malaria drug, is the latest and one of the most consequential examples of Trump and public-health authorities not being on the same page in the pandemic. His statement came on a weekend when Trump also misrepresented the facts behind his firing of the intelligence community’s inspector general whose handling of a whistleblower complaint led to impeachment proceedings against the president.

"Fact Check" my ass. Why would anybody depend on two no-name hatchet-men to check any facts over the CIC? It's just outlandish and preposterous that these Democrat hacks purport to "check facts."

[V_TWIN]

Amen. Rule of thumb should be if Chinese lips are movin’ they’re prolly playing fast and loose with the truth.

[billyboy15]

What it does is bring symptoms relief and stop the virus from replicating in the body which allows the immune system to destroy it.

If administered early enough deaths can be severely curtailed.

There is literally NO downside to administering this medication while at the same time there is an enormous upside potential.

[gasport]

“ need to find out how people do after they stop taking the meds 5 days 10days after.”
~~~~~~~~~~~
HCQ has an elimination half-life of ~6 weeks.

[RinaseaofDs]

Only in China can you do a double-blind study during a deadly pandemic. How’d you like to be in the control group?

China truly is a third world country.

[billyboy15]

“Take it,” he said of the drug. For people sick with the coronavirus, he said Sunday, “It can help them but it’s not going to hurt them.” In fact, it may or may not help some people, and it may or may not hurt them.

LOL, well you know taking Aspirin can hurt some people and in any case (Chloroquine etc) it is only to be administered under the direction of a physician.

These hit pieces are far to obvious to have much of an effect on any but already committed Trump haters. There are far to many reports of the success of these drugs to give any credibility to the naysayers.