COVID-19 and the cardiovascular system

Nature ^ | Mar 5, 2020 | Ying-Ying Zheng, Yi-Tong Ma,

[DannyTN]

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells through ACE2 receptors, leading to coronavirus disease (COVID-19)-related pneumonia, while also causing acute myocardial injury and chronic damage to the cardiovascular system. Therefore, particular attention should be given to cardiovascular

[Jane Long]

Do they require Rx? (alldaychemist)

[aquila48]

“I read the abstract and it is really intended to warn physicians who are treating patients with Cardio Vascular Disease (CVD) that may be taking ACE2 inhibitors. The COVID-19 virus spike binds to the ACE2 receptor and can interfere with heart and lung tissue functioning. “

So, does that mean that taking ACE inhibitors helps? That’s what it sounds like. (I’m currently taking Lisinoprin, which is an ACE inhibitor).

This from another source, seem to be saying the same thing... (I’m taking all of these)

“Some experts have suggested that the rigorous use of guideline-directed,plaque stabilizing agents could offer additional protection to CVD patients during a widespread outbreak (statins, beta blockers, ACE inhibitors, ASA)v;however, such therapies should be tailored to individual patients”

[steve86]

I thought that was just a restriction on select products for which ingredients are running low (in India). My usual Indian Pharmacy website has no notice concerning general restrictions. Their whole business is export from India.

[steve86]

I take an ARB (losartan). There is pro and con evidence for both ACE inhibitors and ARBs.

[steve86]

I haven’t dealt with them but the Indian online pharmacies generally don’t.

[Aria]

What is your educational and career background that enables you to determine that this virus isn’t dangerous and we’re all a bunch of fools for worrying about it?

[aquila48]

FYI. Very informative article on Losartan vs Lisinopril.

https://www.singlecare.com/blog/losartan-vs-lisinopril/

[krogers58]

No, none is needed to order.

[steve86]

ARBs provide renal protection which ACE inhibitors don’t. And without the coughing.

Regarding interfering with ACE2 binding by coronavirus, much of the research is using animal models and does not seem to be readily replicable (for either drug).

[Ancesthntr]

Looking forward to hearing (well, seeing) what you think about both links. You are an out-of-the-box thinker, and lots of great things come from people like that.

[krogers58]

I note that your links both describe the ways that anti-parasitical drugs seem to have broad uses in cancer. It, frankly stuns me, but I am not well-versed in cancer, nor it's treatments. I'd also say, it is the simplest powers of observation, where the doctors in the second study had lab mice whom they could not "infect" with a particular tumor. Checking backwards, they noticed they were all fed that anti-parasitical. Such is the beauty of observant scientists. Miracles in medicine seem to come from anecdotal stories (penicillen) and simply stubling into something game changing.

I think that to control viruses, while anti-virals are important, anti-virals will need to be combined with other therapies, such as these anti-parasiticals to be truly effective.

[steve86]

Here’s one review study where overall, ACE worked but ARB didn’t

https://www.ncbi.nlm.nih.gov/m/pubmed/22786934/

Still had it open in a tab

[steve86]

meant for previous comment to be directed to you

[Secret Agent Man]

already knew from other articles it can cause permanent damage to lungs, if not killing the person from the lung damage.

then today also they confirm it can in some cases cause central nervous system damage verified by mri’s and presence of encephalitis.

i am sure certain demographics are more susceptible to these occurring than others.

[wafflehouse]

dude, dont feed the trolls

[DAC21]

I notice ADC asks for your Doctor’s phone number. Are they actually going to call, or do they ask to just cover their a$$?

I figure if I’m going to order I’d also pick up some Amoxicillin / Azithromycin. Obviously I have no prescription.

[HartleyMBaldwin]

bfl

[Freeport]

I would assume they are referring to scare tissue?

[JohnBovenmyer]

It would be interesting to compare patients on ACE inhibitors vs. those on ARBs. Latter blocks the same pathway, but at a different site, the receptor. Both work similarly for cardiovascular disease, but latter might also block out the virus.

[Ancesthntr]

What I would be truly interested in is whether Fendbendazole (2nd link) can be used to fight this CV. It is available cheaply on Amazon without any prescription necessary, but it is incredibly cheap. I do know that if I ever get cancer, one of my first acts will be to order it and follow the protocol in the article. Not much to lose in that situation.

I wonder if it would help Rush? I don’t think that it is applicable to every type of cancer, but perhaps it is because it denies the disease the sugar it needs for energy. It clearly hasn’t been studied enough to know, because there’s no money to be made.