[zeestephen]

Can Air Force One fly Washington D.C. to Afghanistan non-stop?

7,000 miles - according to Google.

However, flying east from D.C. - there are no straight line routes, unless you fly in air space over Russia, or Syria, or Iran.

The only “safe” route I see would be over Israel, Jordan, Saudi Arabia, U.A.E. or Oman, then north over Pakistan.

I have to think a lot a bad guys would notice Air Force One flying near their neighborhood.

[Gay State Conservative]

Of course it can.IIRC Air Force One can be refueled mid air.But even if that's not true just about every modern jumbo can fly non-stop 12 hours plus. I once flew a 777 for 15 hours 55 minutes.

[jjotto]

Great circle route wouldn’t require too much detour.

[wastedyears]

Air Force One can refuel in air.