These maladies have been with the world for centuries, if not eons.
I imagine cavemen had much the same things happening, if on a smaller scale.
(Hey! Ugh's tribe has a lot more women, mastodon ribs, and firewood than we do. Let's go take some.)
California used to burn at a rate four or five times the current rate before 1800. Very large parts of the Central Valley used to burn yearly.
https://www.hcn.org/issues/251/13986