“Start by substantiating your LD50 number.”
I am just using the numbers from the papers linked, I am not making up my own. the 30 mg/kg came from a more recent study (2014), but the 130 mg/kg came from monkeys, which are generally a closer approximation for humans (of course, lethal testing is not conducted on humans).
You are of course welcome to conduct your own searches, for an LD50 you assess to be more reliable. I would recommend that, before flippantly casting aspersions on other people for doing so.
“Using the much lower number for intravenous dosage is extremely misleading. One might call it an outright lie.”
It would be a lie, to call it a lie. I am specifying the methodology of the study - highlighting it - not trying to hide or misrepresent it. If you read the rest of the thread, you will see that we discuss oral, IV and inhaled.
I saw one study which said that inhaled LD50 was a LOWER dose than IV, and did not post or mention it, because it seems counter-intuitive to me.
THC is a potent agonist for dopamine. Concentrates allow people to take 1,000 effective doses at once. Of course there are going to be significant effects. High doses raise heart rate and blood pressure - the same mechanism by which it kills across the species tested for LD50 (rats, dogs and monkeys).
LD50 is an average - individuals will vary. LD50 kills one out of two, on average - but some lower dose will be fatal for one out of a hundred, or one out of 100,000. There is a point where people start dying, and it looks like it is some number of grams of pure THC, well under an ounce (likely under 10 grams, for a small person vaping concentrated THC oil (80% or better) in a rapid manner).
Swallowing a big mouthful of such oil would likely threaten most people’s lives.
So it is not some mild substance, like olive oil or honey. People can be fatally poisoned with it. Below the lethal dose, they will be profoundly hallucinating.
“There is a point where people start dying, and it looks like it is some number of grams of pure THC, well under an ounce (likely under 10 grams, for a small person vaping concentrated THC oil (80% or better) in a rapid manner).”
From even a casual search this is not typical usage.
People report weeks to months of use from a 1 gram vape pen.
Edible THC products appear to contain 2-20mg per dose.
So who is really taking 1000 effective doses at once?
This is like saying Dulce De Leche allows people to do the same with sucrose.
Sucrose (table sugar) LD50 : g/kg 29.7
Dulce De Leche Sugar per cup: 151g (37.8 tsp)