Given that this beast is gonna be a Cat 4 or 5 storm, if you're thinking about bugging out at all, I'd be ready to roll no later than 24 hours before landfall... probably 36 since it's gonna be slowing down. If I were there, I'd be heading to Naples or Everglades City.
If the forecasts have it landing anywhere within 50-70 miles of your location at that point, then that would be a good enough indication to leave. You could definitely expect hurricane force winds anywhere in that window to wherever the landfall 'point' is... and maybe a bit further.
You could also expect those winds to linger for a full day. God have mercy on anyone enduring the eye wall for all of those hours.
Right now, the models are starting to converge, but all points from Ft. Lauderdale to Ft. Pierce are definitely in play... with changes still quite plausible since it's still 3-4 days out.
(But face it: the entire Atlantic Coast from Miami to at least Hilton Head could get thrashed)
