The issue in Los Angeles and some other major cities is that people are buying apartment buildings, evicting all the tenants, then turning them into de facto hotels, renting out the units through AirBnB while avoiding any of the regulations and taxes on hotels. This cuts the rental housing stock, driving up costs for renters and pricing some out of the market, with all that entails.
That may be a good place for a narrowly defined regulation as it impacts the stand alone AirBnBs, such as no more one rental per 10,20,30 (pick a number) total units to owned by a single or related entity.