Well worth watching for SciFi fans IMHo.
The reason I don’t accept that the Universe is a simulation is closely related to the reason I don’t believe it is the work of a supernatural intelligence. The demonstration of quantum entanglement and its proof that the observed behavior can not be attributed to “hidden variables” means that any simulation would need to be able to transmit information faster than the speed of light. Since the simulation would also be subject to this limit it would be impossible to simulate. The other part of the argument is that quantum behavior like radioactive decay is truly random in time unlike any other deterministic behavior like coin tossing whose randomness is really just due to our ignorance of all the forces and initial conditions that preceded the observation of heads or tails. God would of course know whether the coin would come up heads or tails but even He could never know when a neutron would decay in a radioactive material. If there is information in the system that is beyond even God then He can’t be the supreme being and the creator of everything. There would have to be higher laws or principles that even He was subject to.
Of course, in the end, this extreme skepticism (everything is a simulation) gets us back to Descartes and the ONLY thing that he was certain of was that he existed. "I think therefore I am." Neil deGrasse Tyson and Elon Musk are just two more examples of what the Bible calls "fools." They are willing to believe anything (including being in a simulation) in order to justify themselves thinking that there is no god that they are accountable to.