Commentators in California have observed that Sen. Harris is widely disliked in California politics, and that California politicians are widely disliked in the rest of the country. Presidential candidates, as Hillary Clinton learned, have to win votes, not just in California, but in states full of people they hate.
It has also been pointed out that educated, single, white, feminist women (a substantial group of Democrat primary voters), may not go for the married politician’s amply-rewarded whore.