It puzzles me that some people consider using the stuff a form of recreation.
I knew a guy who was getting opioids from multiple doctors for “recreation”, but really because he was addicted. After 25 years of that he was taking about 5 times normal dose a day. He’s dead, heart failure at 67.
I of course can’t speak to how much effect on his heart was due to the drugs. He liked Vicodin, I know that.