So, any time after Thursday and subject to Senate debate and cloture rules McConnell can call the vote. He won't do so, of course, without 50 votes (meaning he doesn't need Flake's) but, without any Democrats/Leftists, he'll need all Republicans including Murkowski and Collins who agreed with the Judiciary Committee's recommendation (one week for the FBI to complete a supplemental investigation). As is so often the case, it's up to these two to conclude that because there have been sufficient investigations (including this most recent one), because no new evidence has been presented and because of Kavanaugh's nearly four decades of impeccable performance and credentials he has earned their votes ... and the Democrat/Left can do nothing to stop confirmation.
This, simply put, is what it comes down to.
There is a 2-day wait after cloture passes
So a Fri confirmation vote requires a Wed cloture vote