Only the state wants the tax. The other juirisdictions get the money from the state. They do not get it from you. You have to file in 50 states and I am by no means trivializing that. It will be time consuming or you will have to give up a chunk of profit for some service.
As you collect tax for those 10,000 (actually 7,000) jurisdictions, there are services that will tell you how much to collect. Those services cost about 10 cents per transaction. There is no effort involved, just that fee. Then, like I said, you have to file in 50 states, probably quarterly depending on amounts which will be time consuming unless you pay for a service to file for you.
Sooooo who pays the difference between the state tax; the state tax plus the county tax; the state tax, plus the county tax, plus the city tax; the state tax, plus the county tax, plus the city tax, plus any special assessments?
Hint, it isn't the state.
For bonus points, guess who gets stuck with the fines, penalties, and interest for any missing or late taxes.
For full credit, guess which court claims jurisdiction and demands your physical presence in their court, tomorrow at 9:00 AM, if you don't drop everything, and bend to their will, you loose everything in a summary judgment.
Nice, you don't have to report what was sold (is there a tax on this particular product in this particular jurisdiction, sub-jurisdiction, or sub-sub-jurisdition??? Do they just guess?) How much it cost, who it was sold to, when, what was the shipping address, was it the same as the billing address, else how can they tell if there's a separate tax for that jurisdition?
God help you if your data entry clerk (that you had to hire to track all this crap) makes a data entry error.