England's Queen Mary I married her first cousin, and Queen Mary II also married her first cousin. Both marriages were childless.
But again, what is the cumulative effect of inbreeding & incest in the right here and now?
I say it is Islam, which comes against us as the Destroyer. Its victims are now piling up in anonymous heaps as were those of the Holocaust. We in the West are as yet mostly blissfully unaware. God help us for that.