The cause of a cleft palate isn't certain, but women who smoke, take certain medications, are diabetic and more are more likely to have a baby with a cleft palate.
Reporters have misrepresented studies by stating homosexuals are more likely to be left handed, have longer fingers, a different size hypothalamus and more, all of which were debunked years ago. Now some scientists who are gay are stating there's nothing in genetics to support the born that way theory.
We also have ex-gays, some of whom ran gay magazines (Charlene Cothran ran Venus Magazine for lesbians, Michale Glatz co-founded Young Gay America.) Dennis Jernigan is now a Christian songwriter and many, many more.
There are LUGs (Lesbian Until Graduation).
There are those who choose the life (http://queerbychoice.com) and if you read some of my links above you'll find more who admitted to choosing the life.
We don't do ourselves any favors by ignoring all the evidence.
Are you saying Down Syndrome is meant to be, by Gd? Maybe it is. I can’t begin to understand. I know from caring with people with special needs that they are perfect just the way they are. I think Gd sets up the world and things just combine in weird ways, obstacles happen, and we must get through them, get past them, and love each other.
There is a very short window of time toward the later part of the first trimester, in which the brain / sex organ / gender / decisions are made. Clearly something environmental affects some of those determinants. There are more gender dysphoria, more homosexuality, more hypospadias, more ovarian problems, than generations before.
Not everyone gay chooses to be gay. Most do not.