Depends upon how the disks are set up. If /home is on a separate disk, like I have it now, I might well leave it alone. I've gone back and forth on using LVM on /home, which will often influence things as well, because I really hate working with LVM, and have since IBM first introduced it in AIX (though SMIT actually made dealing with it not as painful as it otherwise can be). I've actually thought about using the ZFS file filesystem, since disks are getting to be so humongous these days. I still find it hard to believe that I have multi-terrabyte disks.
One thing to remember when doing an install is that it is really important to unplug the drives. I had an external (backup) drive plugged in during a Fedora install years ago and did not notice that Fedora had helpfully added the external drive to the LVM when it formatted and configured the disks. Had to fall back to my secondary backup that time. Lost a bit of data because of my inattentiveness.
Yeah—I left LVM a while ago in regards to my laptop (dual HW RAIDed HDD), and just went to standard partitions. It makes things a lot easier when doing a clean install as I can just leave that /home partition alone during the customized partitioning step.