Of course R’s will lose seats. Partly because of McConnell and a few more like McShame & Lindsay, Flake, Collins, Romney, Bush, Kaysuck of Ohio, etc.
Most folks look at these types and want to throw up
Well Flake is not running for reelection, which is a good thing and McCain is not up for reelection. He should have retired though, instead of running for reelection in 2016