I’ve been happy with MWB as a the sole gate-keeper and scanner for several years. When the notion strikes, I’ll run a Spybot scan just for grins.
I’ve had Kaspersky and MWB both for about five years and Kaspersky is up for renewal in about three weeks. I might give MWB alone a try. Actually, I got MWB Premium for life, for only $18.00 several years. That was when they first started charging for some packages after they’d had that free one for several years.