G H W B yes
I remember a press conference when GHWB was President. It was a joint press conference with a leader from a foreign country, possibly Israel. They were outside at the time. Might have been at the Bush Compound in Maine. A female reporter from CNN, possibly Jeanne Moos asked him if there was any truth to the rumors about an affair. At the time I thought it was pretty bad taste to ask that question when he was in the company of another world leader, and GHWB told her that under no circumstances would he even consider responding to her question, and that he felt it was a totally inappropriate question at the joint press conference. That was the last I ever heard of any alleged affair, until you mentioned it in this thread.