Going to Single Payer will likely abort that sea change if it is not ready to roll out and cheap enough that high prices are required through a patent period. Those high prices will not be paid by the government in a SS system and fantastic advances will be put back in the drawer. Get the government totally out of medicine and we will have some very rapid and paradigm changing new developments in practice.
Look up fecal matter transplants. It’s definitively possible to DIY and big pharma can’t touch it.