Diminishing returns says too large of a radius makes the airport an impractical giant. On the plus side, urban encroachment will not diminish runway length.
Remember, it was initially difficult to land airplanes on a ship. It was thought to be very dangerous to land the shuttle in the glide mode with no go-around capability. Some people are stuck on the concept that future airplanes with be still configured as they are today.
IF future planes have a different configuration then we can look at how airports should be configured