So say you, but not the Constitution. Article V is for AMENDING the Constitution, not enforcing it.
Review the basic assumptions of the Constitution as confirmed by the Ninth and Tenth Amendments. The states are constitutionally sovereign outside constitutionally delegated authority of the feds. The states have not only the constitutional right but the DUTY to resist and nullify unconstitutional federal acts which, as I say, is the very definition of tyranny.