He might surprise with something new, but he does stick to his memes. I don't see him invoking any that don't involve Trump. The Cruz/Carly ticket's appeal has been sold as an antidote to Trump. Cruz might get challenged on naming a running mate given his position in the race, and that is the opening for "most conservative, proven track record" and "Trump/Hillary are two sides of the same disease" spiels.
At least at this point he has not argued that he can win on the first ballot, only that he can win on later ballots. In this stance, he pretty much has to contrast his prospects in the general with those of Trump, as well as claiming that Trump will destroy the GOP.
It may not change the race but it would give conservatives something to cheer about.