When legislating rather than constitution writing there is always the temptation to venture into areas of self or in the case you mention regional interest.
It was national interest in the view of Hamilton, the driving force behind the bill. It was expressly intended to give protection to American manufactures.
https://en.wikipedia.org/wiki/Report_on_Manufactures
“The Report on the Subject of Manufactures, generally referred to by its shortened title Report on Manufactures, is the third report, and magnum opus, of American Founding Father and 1st U.S. Treasury Secretary Alexander Hamilton. It was presented to Congress on December 5, 1791 and recommended economic policies to stimulate the new republic’s economy and ensure the independence won with the conclusion of the Revolutionary War in 1783.
It laid forth economic principles rooted in both the Mercantilist System of Elizabeth I’s England and the practices of Jean-Baptiste Colbert of France. The principal ideas of the Report would later be incorporated into the “American System” program by Senator Henry Clay of Kentucky and his Whig Party. Abraham Lincoln, who called himself a “Henry Clay tariff Whig” during his early years, would later make the principles cornerstones, together with opposition to the institution and expansion of slavery, of the fledgling Republican Party.
Hamilton’s ideas formed the basis for the American School of economics.”