For most of the 19th century, the most important dividing issue between Republicans (and their Federalists/Whig predecessors) and Democrats (Democratic Republicans) was tariffs vs. free trade.
>> Washington and Hamilton realized that without protective tariffs, the US would not become a manufacturing power, it would be an economic backwater selling raw material and agricultural goods to Europe <<
I don’t know about Washington’s position. Never studied it. But you’re correct about Hamilton. And Hamilton was flat-out wrong on the matter, as were Henry Clay and countless other Whigs, Free Soilers and Republicans. But I’ll give them a pass on the issue, since they opposed and ultimately abolished slavery.