How is that possible when none of the sucralose is metabolized by your system? It is non-caloric because it is not absorbed by the body.
Your fear is unfounded.
Sugar Substitutes, Gut Bacteria, and Glucose Intolerance.
The consumption of artificial sweeteners results in glucose intolerance mediated by changes in the gut microbiota in both mice and humans, researchers report.
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Sucralose is manufactured by the selective chlorination of sucrose (table sugar), in which three of the hydroxyl groups are replaced with chlorine atoms to produce sucralose.
Sucralose - with its appended chloride groups - has been shown to increase the acidity of the entire GI tract. When the pH is unbalanced like this, the good bacteria suffer. Even minimal amounts can increase acidity and damage good bacteria. To make matter worse, the changed pH levels persist for weeks or months after the sucralose is stopped.
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Though the digestive tract has anywhere from 300-1000 different kinds of bacteria, only 30-40 usually dominate, taking almost all of the available space. They suppress the other bacteria and many pathogens simply by denying them room to grow.
In turn, about 66-75% of this 30-40 kinds of bacteria are aerobic (oxygen loving) bacteria of the Firmicute phylum. They are more recently evolved, and are very efficient in digesting the food we eat, in our upper GI tract and small intestine.
About 25-33% of this 30-40 kinds of bacteria are anaerobic (oxygen hating) bacteria of the Bacteroidetes phylum, that mostly occupy our large intestine. They are evolutionarily very old, and are far less efficient in digesting our food, preferring to digest fiber that we cannot digest at all.
The balance between the two phylum of bacteria matters, because if there is a higher ratio than typical of Firmicutes, you have better nutrition and tend to gain weight. With a higher ratio of Bacteroidetes, you tend to lose weight.
From that point, individual kinds of bacteria enter the picture. The genus Enterobacter, for example, is strongly associated with weight gain, and can on its own dominate the intestinal flora. When people become obese, as much as 1/3rd of their flora can be Enterobacter, displacing all others.
And Enterobacter is not affected by Sucralose and other artificial sweeteners at all, while it is devastating to both the Firmicutes and Bacteroidetes. And the icing on the cake is that it may so deplete your good bacteria that it exposes you to dangerous or even deadly blooms of drug resistant bacteria.