This action is skirting constitutional problems imo. More specifically, the Supreme Court has historically indicated that the states have never delegated to the feds, expressly via the Constitution, the specific power to quarantine citizens for health purposes.
”State inspection laws, health laws, and laws for regulating the internal commerce of a State, and those which respect turnpike roads, ferries, &c. are not within the power granted to Congress. [emphases added]” —Gibbons v. Ogden, 1824.
“Inspection laws, quarantine laws, health laws of every description [emphasis added], as well as laws for regulating the internal commerce of a state and those which respect turnpike roads, ferries, &c., are component parts of this mass.” —Justice Barbour, New York v. Miln., 1837.
Note that I agree with the CDC's request in principle. But let's amend the badly neglected Constitution so that the federal government can make such requests within the framework of the Constitution.
So, if a man said “To hell with you! I’m going home!” It would take some very stupid people to wrestle with him.