Not so much for marijuana - plants grow more or less as they have always grown.
Our technology is so amazing that NEW compounds have been made/created that when used will totally debilitate a person.
And the motivation to make and use these new compounds was provided largely by the ban on older substances.
Even those who seek legalization should be forced morally to support CONTROLLED ACCESS and not open access.
That's what I support, for alcohol and other drugs.
Application of scientific agriculture has greatly increased the potency of marijuana. And we've not talked yet about genetic modification. So the science in the field and in the lab has produced some terrible new choices.
Controlled access is the best answer out there at the moment, imo.