10th Amendment “prerogatives” are Constitutionally constrained under Article 1, Section 8, as follows:
To make all Laws which shall be necessary and proper for carrying into Execution the foregoing Powers, and all other Powers vested by this Constitution in the Government of the United States, or in any Department or Officer thereof.
So, in a word, regarding mj....NO!
IOW, you support the expansive New Deal Commerce Clause - the same Commerce Clause view that has allowed fedgov control of health care, education, the environment and a host of other big govt programs.
You've given up any constitutional argument against such fedgov overreach at the expense of the 10th Amendment.