Yes, absolutely. Think of what the pilgrims experienced, and all of the waves of immigrants thereafter.
You’re preaching to the choir, here. I have ancestors from the Mayflower and the Anne, and also some pretty hardy Pioneers. A lot of us in the West are from the same stock...which explains why my late ex-sister-in-law was also my fifth cousin once removed!
SiL on my mother’s side, cousin on my dad’s side.