Except that the supremacy clause is only for things pursuant to the Constitution itself — in all other cases it is legal nullity [as affirmed by the 9th and 10th Amendments]. Therefore, just because the government says [e.g.] drugs are illegal, does not make drugs illegal — indeed, the Constitution had to be amended in order to make it possible for the federal government to make alcohol illegal.
I apologize for the confusion. I agree with you about federal courts’ extra-Constitutional upholding of increased federal powers.
I thought my statement about Marbury v. Madison gumming up the works revealed how I feel about over-reaching power of federal courts.