(2) Double blind studies are only one variety of clinical study. They are not prescriptive, and not the only way to derive reliable statistical information.
How would you mitigate the placebo effect ? Prescribing SSRIs to normal people will cause mental instability.
They are psychotropic drugs.
The placebo effect is completely irrelevant - so many people have been taking SSRIs for so many years that you can run the statistics directly. There is no need to project what might happen - we have enormous data sets chronicling what already has happened.